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by Thalia Herzog 10 min read

MS is an immune-mediated disease affecting the brain and spinal cord, also called the central nervous system (CNS). MS can appear at any age but most commonly manifests between the ages of 20 and 40. It affects women two to three times as often as men.

What are usually the first signs of MS?

Common early signs of multiple sclerosis (MS) include:vision problems.tingling and numbness.pains and spasms.weakness or fatigue.balance problems or dizziness.bladder issues.sexual dysfunction.cognitive problems.

How does MS usually start?

Here's where MS (typically) starts Although a number of MS symptoms can appear early on, two stand out as occurring more often than others: Optic neuritis, or inflammation of the optic nerve, is usually the most common, Shoemaker says. You may experience eye pain, blurred vision and headache.

What is the life expectancy in MS?

Survival and all-cause mortality analyses Median life expectancy for all patients with MS was 74.7 years, compared with 81.8 years in the general population (figure 1A). Median survival from disease onset of MS was 40.6 years compared with 54.6 years in the general population (figure 1B).

What does MS do to a person?

Multiple sclerosis (MS) is a disease of the central nervous system that can affect the brain, spinal cord and optic nerves. Common symptoms include fatigue, bladder and bowel problems, sexual problems, pain, cognitive and mood changes such as depression, muscular changes and visual changes.

What does MS feel like in legs?

The weakness can make your legs feel heavy, as if they are being weighed down by something. They may also ache and hurt. Some people with MS describe it as like having bags of sand attached to their legs. This muscle weakness combined with MS fatigue can be upsetting.

When should you suspect multiple sclerosis?

People should consider the diagnosis of MS if they have one or more of these symptoms: vision loss in one or both eyes. acute paralysis in the legs or along one side of the body. acute numbness and tingling in a limb.

What are the four stages of MS?

What are the 4 stages of MS?Clinically isolated syndrome (CIS) This is the first episode of symptoms caused by inflammation and damage to the myelin covering on nerves in the brain or spinal cord. ... Relapsing-remitting MS (RRMS) ... Secondary-progressive MS (SPMS) ... Primary-progressive MS (PPMS)

Can MS go away?

Multiple sclerosis is a chronic condition, which means it's long-lasting, and there's no cure for it. That said, it's important to know that for the vast majority of people who have MS, the disease isn't fatal. Most of the 2.3 million people worldwide with MS have a standard life expectancy.

Is MS curable if caught early?

There is no cure for MS (multiple sclerosis), but early, aggressive treatment at the earliest signs of the disease can prevent recurrent attacks.

Can Covid 19 cause MS?

Segal says. “Some people with COVID-19 infections experience neurological symptoms that may be secondary to this response. MS is caused by an abnormal immune response targeting the central nervous system. This raised concerns that COVID-19 could exacerbate MS.”

Is MS a serious disease?

Multiple sclerosis is not generally the cause of death, but it can be a severely disabling condition. People with MS live slightly less long than those without the condition. This may be due to disease complications or other associated medical problems.

How is MS diagnosed?

An MRI scanner uses a strong magnetic field to create a detailed image of inside your brain and spinal cord. It's very accurate and can pinpoint the exact location and size of any inflammation, damage or scarring (lesions). MRI scans confirm a diagnosis in over 90 per cent of people with MS.

Do MS symptoms come on suddenly?

Symptoms. Most commonly, MS starts with a vague symptom that disappears completely within a few days or weeks. Symptoms can appear suddenly and then vanish for years after the first episode, or in some cases never reappear. The symptoms of MS vary greatly and can range from mild to severe.

At what age is multiple sclerosis usually diagnosed?

It's most commonly diagnosed in people in their 20s, 30s and 40s although it can develop at any age. It's about 2 to 3 times more common in women than men. MS is one of the most common causes of disability in younger adults.

What can trigger MS?

Multiple sclerosis (MS) triggers include anything that worsens your symptoms or causes a relapse....Here are some of the most common triggers you may experience with MS and tips to avoid them.Stress. ... Heat. ... Childbirth. ... Getting sick. ... Certain vaccines. ... Vitamin D deficiency. ... Lack of sleep. ... Poor diet.More items...•

How long does MS take to develop?

Most symptoms develop abruptly, within hours or days. These attacks or relapses of MS typically reach their peak within a few days at most and then resolve slowly over the next several days or weeks so that a typical relapse will be symptomatic for about eight weeks from onset to recovery.

What is MS in medical terms?

What Is MS? Multiple sclerosis (MS) is an unpredictable disease of the central nervous system that disrupts the flow of information within the brain, and between the brain and body. WILLIAM.

What is the cause of MS?

The cause of MS is still unknown. Scientists believe that a combination of environmental and genetic factors contribute to the risk of developing MS. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted. Most people with MS are diagnosed between the ages of 20 and 50, with at least two to three times more ...

Signs and symptoms

A person with MS can have almost any neurological symptom or sign, with autonomic, visual, motor, and sensory problems being the most common.

Causes

The cause of MS is unknown; however, it is believed to occur as a result of some combination of genetic and environmental factors such as infectious agents. Theories try to combine the data into likely explanations, but none has proved definitive.

Pathophysiology

The three main characteristics of MS are the formation of lesions in the central nervous system (also called plaques), inflammation and the destruction of myelin sheaths of neurons. These features interact in a complex and not yet fully understood manner to produce the breakdown of nerve tissue and in turn the signs and symptoms of the disease.

Diagnosis

This article needs to be updated. Please help update this article to reflect recent events or newly available information. (July 2020)

Types and variants

Several phenotypes (commonly termed types ), or patterns of progression, have been described. Phenotypes use the past course of the disease in an attempt to predict the future course. They are important not only for prognosis but also for treatment decisions.

Management

Although there is no known cure for multiple sclerosis, several therapies have proven helpful. The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. Starting medications is generally recommended in people after the first attack when more than two lesions are seen on MRI.

Prognosis

The expected future course of the disease depends on the subtype of the disease; the individual's sex, age, and initial symptoms; and the degree of disability the person has.

What is MS in medical terms?

What is multiple sclerosis (MS)? Multiple sclerosis (MS) is a chronic disease affecting the central nervous system (the brain and spinal cord).MS occurs when the immune system attacks nerve fibers and myelin sheathing (a fatty substance which surrounds/insulates healthy nerve fibers) in the brain and spinal cord.

How does MS affect the brain?

This attack causes inflammation, which destroys nerve cell processes and myelin – altering electrical messages in the brain. MS is unpredictable and affects each patient differently – some individuals may be mildly affected, while others may lose their ability to write, speak or walk.

What are the symptoms of multiple sclerosis?

This form of multiple sclerosis is characterized by the onset of the neurological symptoms over a period of hours to days. Common symptoms of a relapse may include: Fatigue. Numbness. Tingling.

Does MS have a relapse?

They often describe heaviness and stiffness in the lower limbs. People with primary-progressive MS almost never have an exacerbation (relapse). If a relapse occurs after a primary progressive course is well established, the pattern is known as Progressive-Relapsing MS.

Is MS relapsing or remitting?

All those with secondary progressive MS began the disease with a relapsing-remitting disease course. In secondary progressive MS, symptoms accumulate and worsen without any remission. There may be periods where symptoms are stable, but the overall course is one of worsening over time.

What does "ms" mean in English?

(normally / ˈmɪz /, but also / məz /, or / məs / when unstressed) is an English-language honorific used with the last name or full name of a woman, intended as a default form of address for women regardless of marital status. Like Miss and Mrs., the term Ms. has its origins in the female English title once used for all women, Mistress.

Where did the term "Ms" come from?

Like Miss and Mrs., the term Ms. has its origins in the female English title once used for all women, Mistress. It originated in the 17th century and was revived into mainstream usage in the 20th century. In the UK and the majority of Commonwealth countries, a full stop is usually not used with the title; in Canada and the United States ...

What was Miss Michaels looking for in a title?

Michaels "was looking for a title for a woman who did not 'belong' to a man". She knew the separation of the now common terms Miss and Mrs. had derived from Mistress, but one could not suggest that women use the original title with its now louche connotations.

Why is "ms" a misfit?

The Queen's English Society has criticised the use of Ms as "an abbreviation that is not short for anything", describing it as a "linguistic misfit [that] came about because certain women suddenly became sensitive about revealing their marital status".

When did Gloria Steinem use the title "Ms."?

In 1969 , during a lull in an interview with The Feminists group on WBAI -FM radio in New York City, Michaels suggested the use of Ms. A friend of Gloria Steinem heard the interview and suggested it as a title for her new magazine.

When was the Simplified Letter issued?

The term was again suggested as a convenience to writers of business letters by such publications as the Bulletin of the American Business Writing Association (1951) and The Simplified Letter, issued by the National Office Management Association (1952).

When was the word "Ms" popularized?

The earliest known proposal for the modern revival of Ms. as a title appeared in The Republican of Springfield, Massachusetts, on November 10, 1901: There is a void in the English language which, with some diffidence, we undertake to fill.

What is the most common form of MS?

During remission periods, symptoms are mild or absent, and there’s mild to moderate disease progression. RRMS is the most common form of MS at onset and accounts for about 85 percent of all cases, according to NMSS.

What does it mean when you have progressive MS?

If you have primary progressive MS (PPMS), neurological function becomes progressively worse from the onset of your symptoms. However, short periods of stability can occur. The terms “active” and “not active” are sometimes used to describe disease activity with new or enhancing brain lesions.

What is demyelination in MS?

Demyelination is a process that prevents nerves from efficiently sending signals. A diagnosis also requires ruling out other conditions that have similar symptoms. Lyme disease, lupus, and Sjögren’s disease are just a few examples. Learn more about the tests used to diagnose MS.

What is CIS in MS?

Clinically isolated syndrome (CIS) CIS is a pre-MS condition involving 1 episode of symptoms lasting at least 24 hours. These symptoms are due to demyelination in your CNS. Although this episode is characteristic of MS, it’s not enough to prompt a diagnosis.

How many people with MS have a rare attack?

About 10 to 15 percent of people with MS have only rare attacks and minimal disability 10 years after diagnosis, according to NMSS. It’s generally presumed they’re not on treatment or injectable medications. This is sometimes called benign MS.

What percentage of people with MS report fatigue?

Around 80 percent of people with MS report having fatigue, according to the National Multiple Sclerosis Society (NMSS). Fatigue that occurs with MS can make it harder for you to go about your everyday tasks.

What is the risk of living with MS?

Living with MS. Risk factors. Complications. Statistics. Takeaway. Multiple sclerosis (MS) is a chronic condition involving your central nervous system (CNS). With MS, your immune system attacks myelin, which is the protective layer around nerve fibers. MS causes inflammation and temporary lesions. It can also lead to lasting lesions caused by scar ...

How does MS affect the immune system?

Much of the immune response associated with MS occurs in the early stages of the disease. Aggressive treatment with these medications as early as possible can lower the relapse rate, slow the formation of new lesions, and potentially reduce risk of brain atrophy and disability accumulation.

What is the best test for MS?

Neurological exam. Neurological exam. A complete neurological exam and medical history are needed to diagnose MS. There are no specific tests for MS. Instead, a diagnosis of multiple sclerosis often relies on ruling out other conditions that might produce similar signs and symptoms, known as a differential diagnosis.

How to get enough sleep for MS?

Exercise. If you have mild to moderate MS, regular exercise can help improve your strength, muscle tone, balance and coordination.

How do electrodes work for MS?

Electrodes measure how quickly the information travels down your nerve pathways. In most people with relapsing-remitting MS, the diagnosis is fairly straightforward and based on a pattern of symptoms consistent with the disease and confirmed by brain imaging scans, such as MRI.

What tests can be done to check for multiple sclerosis?

Brain MRI scan showing white lesions associated with multiple sclerosis. Your doctor may then recommend: Blood tests, to help rule out other diseases with symptoms similar to MS. Tests to check for specific biomarkers associated with MS are currently under development and may also aid in diagnosing the disease.

Is there a cure for MS?

There is no cure for multiple sclerosis. Treatment typically focuses on speeding recovery from attacks, slowing the progression of the disease and managing MS symptoms. Some people have such mild symptoms that no treatment is necessary.

Can MS be diagnosed with MRI?

In these cases, further testing with spinal fluid analysis, evoked potentials and additional imaging may be needed. Brain MRI is often used to help diagnose multiple sclerosis.

How do you know if you have MS?

Bowel issues like constipation are also common. Read more on bladder control problems and bowel problems with MS.

How to maintain intimacy with MS?

Learn more on how to maintain intimacy when you have MS. Speech problems: MS could cause long pauses between your words and slurred or nasal speech. You might have swallowing problems as the disease advances. Get more information on symptoms of speech and swallowing problems with MS. Thinking problems: It might be hard to focus from time to time.

How old do you have to be to have multiple sclerosis?

People with multiple sclerosis (MS) tend to have their first symptoms between the ages of 20 and 40. Usually the symptoms get better, but then they come back. Some come and go, while others linger. No two people have exactly the same symptoms. You may have a single symptom, and then go months or years without any others.

What is the first brush with MS?

It happens when your immune system mistakenly tells your body to attack myelin, the protective sheath over nerve cells in your brain and spine. You may hear your doctor call this demyelination. It causes scars, or lesions, that make it harder for signals to travel between your brain and your body.

Is it better to compare yourself to someone with MS?

It’s a byproduct of the changes MS makes in your brain and in your life. Because MS varies so much, it's best not to compare yourself with other people who have it. Your experience is likely to be different. Most people learn to manage their symptoms and can keep leading full, active lives.

Can MS make it hard to walk?

Doctors can treat secondary symptoms, but the goal is to avoid them by treating the primary symptoms. Tertiary Symptoms. These are the social, psychological, and job-related problems of life with MS. If MS makes it hard for you to walk or drive, you may not be able to do your job well.

Does MS affect your ability to read?

Some people have severe problems that make it hard to do daily tasks, but that’s rare. MS doesn’t usually change your intellect or ability to read and understand conversation. Find out more on how MS affects the brain and cognition. Tremors: About half of people with MS have them.

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Overview

  • Multiple sclerosis signs and symptoms may differ greatly from person to person and over the course of the disease depending on the location of affected nerve fibers. Symptoms often affect movement, such as: 1. Numbness or weakness in one or more limbs that typically occurs on on…
See more on mayoclinic.org

Signs and symptoms

Causes

Pathophysiology

Diagnosis

Multiple sclerosis (MS), also known as encephalomyelitis disseminata, is the most common demyelinating disease, in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems. Specific symptoms can include double vision, blindness in one eye, muscle weakness, …

Types and variants

A person with MS can have almost any neurological symptom or sign, with autonomic, visual, motor, and sensory problems being the most common. The specific symptoms are determined by the locations of the lesions within the nervous system, and may include loss of sensitivity or changes in sensation such as tingling, pins and needles or numbness, muscle weakness, blurred vision, pronounced reflexes, muscle spasms, or difficulty in moving; difficulties with coordinatio…

Management

The cause of MS is unknown; however, it is believed to occur as a result of some combination of genetic and environmental factors such as infectious agents.
MS is more common in people who live farther from the equator, although exceptions exist. These exceptions include ethnic groups that are at low risk and that live far from the equator such as the Sami, Amerindians, Canadian Hutterites, New Zealand Māori, and Canada's Inuit, as well as group…

Prognosis

The three main characteristics of MS are the formation of lesions in the central nervous system (also called plaques), inflammation and the destruction of myelin sheaths of neurons. These features interact in a complex and not yet fully understood manner to produce the breakdown of nerve tissue and in turn the signs and symptoms of the disease. Cholesterol crystals are believed both to impair myelin repair and to aggravate inflammation. MS is believed to be an immune-me…